Oestradiol (E2) Blood Tests

Oestradiol is a form of oestrogen, which is a female sex hormone. It plays a crucial role in the development and functioning of female reproductive tissues, such as the breasts, ovaries, and uterus. Oestradiol is also important in regulating the menstrual cycle and reproductive system.

In addition to its role in the reproductive system, oestradiol has other significant functions. It helps maintain bone density, supports cardiovascular health, and influences mood and cognitive function. The hormone is produced primarily in the ovaries in premenopausal women and is also produced in smaller amounts by other tissues such as the adrenal glands, fat tissues, and the brain, both in women and in men.

Levels of oestradiol vary throughout a woman's life, being highest during the reproductive years and dropping significantly after menopause.

Testing oestradiol levels can be important for various reasons, such as evaluating fertility, understanding the causes of menstrual irregularities, assessing menopausal status, or monitoring hormone replacement therapy.

Low levels can lead to symptoms such as hot flashes, night sweats, and osteoporosis, while unusually high levels may indicate conditions like ovarian tumors or estrogen dominance.

Oestradiol, although typically associated with women, also plays important roles in men's health. In men, oestradiol is produced mainly by the conversion of testosterone through the action of an enzyme called aromatase, which is present in fat tissues, the brain, testes, and other tissues.

The functions of oestradiol in men include bone health, fertility, brain function, cardiovascular health, fat metabolism and muscle health.

While high levels of oestradiol in men can lead to problems such as gynecomastia (development of breast tissue), erectile dysfunction, and infertility, very low levels are also problematic, as they can increase the risk of osteoporosis and other health issues. Therefore, maintaining a balance of oestradiol is important for overall health in men.

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